Mechanism of bactericidal action of aminoglycosides.
نویسندگان
چکیده
منابع مشابه
Mechanism of bactericidal action of aminoglycosides.
[This corrects the article on p. 341 in vol. 51.].
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Among the pleiotropic effects of aminoglycosides, their irreversible uptake and their blockade of initiating ribosomes have appeared to explain their bactericidal action, while the contributions of translational misreading and membrane damage and the mechanism of that damage have remained uncertain. We now present evidence that incorporation of misread proteins into the membrane can account for...
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The advantages offered by established antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of antibiotic-resistant bacterial strains. This leads to a need for new antibacterial compounds. Recently, we discovered a series of compounds termed lipophosphonoxins (LPPOs) that exhibit selective cytotoxicity towards Gram-positive bacteria that include pa...
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OBJECTIVES Burkholderia cenocepacia (formally a genotype of Burkholderia cepacia complex called genomovar III) has emerged as a serious opportunistic pathogen in individuals with cystic fibrosis. We developed a liposomal antibiotic formulation composed of 1,2-distearoyl-sn-glycero-3-phosphocholine and cholesterol (molar ratio 2:1) to overcome B. cenocepacia's resistance to commonly used aminogl...
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ژورنال
عنوان ژورنال: Microbiological Reviews
سال: 1987
ISSN: 0146-0749
DOI: 10.1128/mmbr.51.3.341-350.1987